KWEM Radio featured live music performance in the years from 1947 to 1955, a pay to play method generating revenue for radio stations who could not make enough money from conventional advertising sponsors and the spinning of records. Unknown artists who appeared on KWEM during the late 1940s and early 1950s were B.B. King, Howlin' Wolf, Ike Turner, Scotty Moore,Stan Kessler,Warren Smith, Paul Burlison and Joe Hill Louis. All of these artists performed live on KWEM, and for many it was their first radio exposure. Listening to KWEM Radio would inspire another young West Memphis area youth, Albert King, to learn to play and he appeared to support his band at the T-99 Club in Oceola, Arkansas. He would launch his career and become a major influence on Eric Clapton, Jimi Hendrix and Stevie Ray Vaughan.
Howlin' Wolf, Hubert Sumlin, Pat Hare, James Cotton and Junior Parker honed their skills at KWEM and ignited the Chicago Blues scene.
Joe Hill Louis began his music career with his own show in 1949. He would record for Sam Phillips that year. Louis moved to WDIA in the early 1950s and replaced B.B. King as the "Pepticon Boy". Louis would also become a Sun Records recording artist and session musician.
Sonny Boy Williamson II had become the most well known musician in the Mississippi Delta while appearing on the King Biscuit Radio Program on KFFA in Helena, Arkansas. Williamson arrived in West Memphis in 1949 and launched his own live daily KWEM program, sponsored by Hadacol Elixir. While at KWEM, Williamson worked with Howlin' Wolf, B.B. King, Junior Parker, and James Cotton, bring his friends from around the delta to perform on his program. These included Elmore James, Houston Stackhouse, Robert Nighthawk (King Biscuit regulars) and Arthur "Big Boy" Crudup. B.B. King made his first radio appearance anywhere at KWEM in 1949, appearing on Williamson's show.
Howlin' Wolf was the first "colored" artist to have his own daily show on KWEM from 1949–1952, before progressing to help create Chicago's electric blues sound.


West Memphis Blues
Elvis Presley's first radio appearance was on KWEM in 1953, performing first with Johnny Burnette and the Rock & Roll Trio, and then with a country group, the Shelby Follin Band. Paul Burlison, guitarist for the Johnny Burnette Trio, had been performing on KWEM since 1949 and played with Howlin' Wolf.
Johnny Cash's first radio appearance when he arrived in Memphis was at KWEM. He had his own weekly show with bandmembers Luther Perkins, and Marshall Grant.
Ike Turner recorded Howlin' Wolf in the KWEM studios in 1951. Scotty Moore and Bill Black both made an appearance on KWEM in 1954.
Johnny Cash recorded a demo of a song he wrote, "Rock n Roll Ruby" in the KWEM studios. The song was recorded by Warren Smith for Sun Records after Cash and Sam Phillips appeared at the Cotton Club and offered Smith's band the chance to record the song.
Presley performed at the Overton Park Shell in Memphis in 1954, alongside KWEM DJs, Texas Bill Strength, and George Kline.
Junior Parker had his own show on KWEM in 1953, before leaving and recording for Chess Records in 1954.
James Cotton also had a programme on KWEM until around 1954, when he joined Muddy Waters as his harmonicist. Cotton also recorded for Chess Records.
Eddie Bond also played on KWEM, whilst his guitarist, Reggie Young, grew up around Blytheville, Arkansas.KWEM's station manager, Dick Stuart, became Carl Perkins' manager. Stuart's brother-in-law, Charlie Feathers, also appeared on the radio station.

KWEM is listed on the National Historic Buildings applications for Sun Studios and Graceland, as having been a major influence on Presley, and the Memphis area in the development and birth of Rock and Roll, along with WDIA